I have highlighted and commented to some of elements under Scoring section below that I found of value, though I strongly advise to go through respective FOA word-by-word to get the strong basis for writing your proposal. Here, the prior research should be preliminary data you may have for the current proposal. It can be either from your previous work or published work from other groups although credit for the work should be stated explicitly in the text and figure captions, if any.
You should also emphasis in your research plan about statistical robustness and benchmarking your experiments to promote research reproducibility and minimize biases. I found this metric to be very important to write a coherent research plan which is well-aligned to my Specific Aims and CDP plan. Idiom - can't see the forest for the trees. Incorrect use of the term synteny. Nat Genet. Before you start writing, make a list of all the stuff you need to write. Only some of the documents have official page limits and the guidelines can be found here.
The main thing to note is that you get 12 pages total for the candidate section plus the research strategy not including the aims. Cover letter: It has a standard format and guidelines can be found here. It must include the list of the people who are submitting reference letters for you. Write this last, after everything else is done. The summary will be visible online to anyone if you get the grant.
Project narrative: sentences on how your project relates to human health. No page limit. Facilities and other resources: Describe the lab space, animal facilities if relevant , computer and office facilities, core facilities at the university, support staff in the lab or the department, and the scientific environment of the lab e.
Make it clear how awesome your lab is for doing research and how you have everything you could ever want. Equipment: Same idea as above, but talk about specific equipment like microscopes, electrophysiology rigs, behavioral setups, PCR machines, etc. Again emphasize how you have amazing stuff that includes everything you could ever want to conduct your research. Biosketch: Use the template online found here and follow all the rules about how many papers you can list, etc.
In the personal statement you want to tell a compelling story about your scientific career. Describe your background, postdoc work, and career goals. In practice, this was the last freaking thing that I was waiting for on the last day after all my materials were done. Hopefully your advisor is not a procrastinator. Each co-mentor needs to submit their biosketch. The budget is super confusing to most of us who have never submitted an R01 or anything like that. People will tell you that your grants office or PO will help you, but for me this was not true and I spent half a day figuring it out.
For the K99 phase years 1 and 2 , you will request salary and research costs. The maximum amounts vary by institute and can be found here. However, your department may not approve you for the maximum salary you can ask them in advance to be safe, or just put down what you want and hope they sign off…. Then you need to calculate the fringe costs on your salary, which is an extra amount that the NIH gives directly to your university for benefits, etc.
People also often allocate money for travel section D , publication costs section F , or other things like animal care costs, training courses, etc. This is money that the NIH gives directly to your institution to theoretically cover the cost of maintaining facilities, keeping the lights on, etc.
Then for the R00 phase things are simpler, but somehow more confusing. Yes, even though that amount is for both direct and indirect costs, you still list it all under direct costs. Repeat this for each of the 3 years of the R00 phase. Budget justification: List the stuff you will buy, the conferences you will go to if you asked for travel costs , and how you calculated animal costs or any other specific expenses. Mention that your requested salary has been approved by the department and is consistent with what other postdocs in your department get.
Mention what fringe rate you used for the calculations. Candidate information: This section is super important! It used to be 3 essays and is now one file, but you should still write three separate sections. Overall, it should convey that you have an awesome background in certain areas but still need to learn more stuff in order to achieve your future goals. Here are guidelines for each essay:. Candidate background: Use different headings to describe different research experiences, e.
Tie them all together, i. You will be a special snowflake destined for success. Training plan: This needs to be very specific about what skills you want to learn in the two years of the K99 phase. I was told to choose things to describe. I chose 5 areas: 3 were technical or analytical skills that I want to gain and the other two had to do with general education broadening my neuroscience background and professional development grant-writing, communication, mentorship.
I mentioned collaborators, a course at Cold Spring Harbor Laboratory, and classes and professional development seminars at my institution. After that, I talked about my interactions with my mentor and collaborators and described how they will supervise me, evaluate my progress, and help me get a job. Specific aims: Everyone will tell you that this is the most important page of your proposal! In one page you need to convince the reviewers that your proposal is significant, exciting, feasible, and will set the stage for your own independent research program.
You should specify which aims will be done during the K99 and R00 phases. Most people have aims. I wrote half a page for each of those sections. For all Activity Codes including each applicable component of a multi-component application.
For all Activity Codes that use an application form with the Specific Aims section including each component of a multi-component application. For Activity Code DP1. For Activity Code DP2. Page Limits Follow the page limits specified below for the attachments in your grant application, unless otherwise specified in the funding opportunity announcement FOA or related NIH Guide notice. I recommend including lots of figures to help with the narration.
The reviewers are likely to appreciate it more than the text. Describe courses, boot camps, and seminars you will attend to complete requirements for responsible conduct of research.
Your university should offer such courses, which you can list here. Description of Institutional Environment 1 page. List the department faculty members who can serve as intellectual resources if needed. Letter of Institutional Commitment 1 page. A letter from the department chair supporting your application and hopefully also providing a subtle recommendation of your candidacy. Resource Sharing Plan 1 page. Describe the data sharing plan including data collected from experiments, custom software etc.
You can also include information conferences you will attend to present your data and submit to peer review. If you conduct wet lab experiments and are planning on using antibodies, cell lines etc. This will enable other labs to replicate your data in the future. Documentation of general reagents that is widely used is not needed. If you are planning on conducting clinical studies you will need to include details on sex, age, race as well as plan to maintain patient privacy.
You will also need to provide an approved IRB protocol at a later date, if your application is approved. Alternately, if you are planning on conducting animal studies, you will need to include justification on number of animals used and also furnish information on approved IACUC protocol.
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